LY2922083 |CAS:1309435-78-6 Probechem Biochemicals

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Chemical Structure : LY2922083

LY2922083 (LY 2922083;LY-2922083)

Catalog No.: PC-60238Not For Human Use, Lab Use Only.

LY2922083 is a potent, selective, orally available GPR40 agonist with EC50 of 9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LY2922083 is a potent, selective, orally available GPR40 agonist with EC50 of 9 nM.
LY2922083 displays no activity against PPARα/β/γ (>10 uM).
LY2922083 demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.

Physicochemical Properties

M.Wt	499.669
Formula	C31H33NO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(4-((5-((2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid

References

1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916.

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LY2922083 (LY 2922083;LY-2922083)

Biological Activity

Physicochemical Properties

References

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