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Chemical Structure : LY2922470
CAS No.: 1423018-12-5
Catalog No.: PC-60236Not For Human Use, Lab Use Only.
LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM.
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LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM.
LY2922470 displays no activity against PPARα/β/γ (>10 uM).
LY2922470 demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.
| M.Wt | 475.603 | |
| Formula | C28H29NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid |
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1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916.
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