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LY305

Chemical Structure : LY305

CAS No.: 1430230-83-3

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LY305 (LY 305;LY-305)

Catalog No.: PC-35133Not For Human Use, Lab Use Only.

LY305 (LY-305) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 2.03 nM, demonstrates potent agonist activity in the aforementioned C2C12 cellular assay (EC50=0.499 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LY305 (LY-305) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 2.03 nM, demonstrates potent agonist activity in the aforementioned C2C12 cellular assay (EC50=0.499 nM).
    LY305 displays little to no affinity for GR, PR and MR (Ki>800 nM).
    LY305 shows the desired muscle and prostate effects in a preclinical ORX rat model.

    Physicochemical Properties

    M.Wt 264.753
    Formula C14H17ClN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-chloro-4-(((1R,2R)-2-hydroxy-2-methylcyclopentyl)amino)-3-methylbenzonitrile

    References

    1. Krishnan V, et al. Andrology. 2018 Mar 12. doi: 10.1111/andr.12479.

    2. Saeed A, et al. J Med Chem. 2016 Jan 28;59(2):750-5.

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