LY3056480 | γ-Secretase inhibitor | Probechem Biochemicals

Chemical Structure : LY3056480

LY3056480 (LY-3056480)

Catalog No.: PC-26917Not For Human Use, Lab Use Only.

LY3056480 is a potent gamma secretase (γ-secretase) inhibitor (GSI), upregulates ATOH1 expression in human intestinal epithelial cell line LS174T with IC50 of 17.3 nM, inhibits Notch signalling and induces hair cell formation.

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Biological Activity

Physicochemical Properties

M.Wt	467.49
Formula	C23H28F3N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4,4-trifluoro-N-((S)-1-(((S)-9-methoxy-3,3-dimethyl-5-oxo-2,3,5,6-tetrahydro-1H-benzo[f]pyrrolo[1,2-a]azepin-6-yl)amino)-1-oxopropan-2-yl)butanamide

References

1. Anne G M Schilder, et al. Nat Commun. 2024 Mar 1;15(1):1896.

2. Silvia T Erni, et al. Front Cell Dev Biol. 2021 Aug 13:9:710159.

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LY3056480 (LY-3056480)

Biological Activity

Physicochemical Properties

References

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