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LY3104607

Chemical Structure : LY3104607

CAS No.: 1795232-22-2

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LY3104607 (LY-3104607;LY 3104607)

Catalog No.: PC-60235Not For Human Use, Lab Use Only.

LY3104607 (LY-3104607) is a potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LY3104607 (LY-3104607) is a potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.
    LY3104607 demonstrates functional potency and glucose dependent insulin secretion in primary islets from rats.
    LY3104607 dose-dependently reduces glucose levels in vivo.

    Physicochemical Properties

    M.Wt 439.515
    Formula C27H25N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(4-((2-(2,6-dimethylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)methoxy)phenyl)hex-4-ynoic acid

    References

    1. Hamdouchi C, et al. J Med Chem. 2017 Dec 13. doi: 10.1021/acs.jmedchem.7b01411.

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