Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LY 3130481
CAS No.: 1610802-47-5
Catalog No.: PC-60899Not For Human Use, Lab Use Only.
LY3130481 (CERC611) is a potent, selective, noncompetitive TARP γ8-associated AMPA receptors with IC50 of 65.3 nM (GluA1/TARP γ-8), with no activity for γ-2 (cerebellum) or other TARP members.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | $958 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LY3130481 (CERC611) is a potent, selective, noncompetitive TARP γ8-associated AMPA receptors antagonist with IC50 of 65.3 nM (GluA1/TARP γ-8), with no activity for γ-2 (cerebellum) or other TARP members.
LY3130481 (CERC611) demonstrates fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists.
| M.Wt | 382.438 | |
| Formula | C19H18N4O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-6-(1-(1-(5-(2-hydroxyethoxy)pyridin-2-yl)-1H-pyrazol-3-yl)ethyl)benzo[d]thiazol-2(3H)-one |
|
1. Gardinier KM, et al. J Med Chem. 2016 May 26;59(10):4753-68.
2. Kato AS, et al. Nat Med. 2016 Dec;22(12):1496-1501.
3. Witkin JM, et al. Neuropharmacology. 2017 Nov;126:257-270.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
