Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Beta-secretase (BACE)-LY3202626
LY3202626

Chemical Structure : LY3202626

CAS No.: 1628690-73-2

Add to Favorites

LY3202626 (LY 3202626, LY-3202626)

Catalog No.: PC-63380Not For Human Use, Lab Use Only.

LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.
    LY3202626 causes dose-dependent reductions in CSF and plasma Aβ concentrations.
    LY3202626 shows potential for the treatment of Alzheimer's disease.

    Physicochemical Properties

    M.Wt 498.513
    Formula C22H20F2N8O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-((4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

    References

    1. McKinzie DL, et al. J Med Chem. 2021 Jun 24;64(12):8076-8100.
    2. Lo AC, et al. J Alzheimers Dis Rep. 2021 Apr 29;5(1):321-336.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: