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Chemical Structure : LY3202626
Catalog No.: PC-63380Not For Human Use, Lab Use Only.
LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 239 nM.
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LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 239 nM.
LY3202626 causes dose-dependent reductions in CSF and plasma Aβ concentrations.
LY3202626 shows potential for the treatment of Alzheimer's disease.
| M.Wt | 498.513 | |
| Formula | C22H20F2N8O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McKinzie DL, et al. J Med Chem. 2021 Jun 24;64(12):8076-8100.
2. Lo AC, et al. J Alzheimers Dis Rep. 2021 Apr 29;5(1):321-336.
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