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Chemical Structure : LY 392098
CAS No.: 211311-39-6
Catalog No.: PC-63023Not For Human Use, Lab Use Only.
LY 392098 is a selective, potent and centrally active positive allosteric modulator of AMPAR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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LY 392098 is a selective, potent and centrally active positive allosteric modulator of AMPAR.
LY 392098 enhances glutamate (100 uM) stimulated ion influx through recombinant homomeric human AMPAR ion channels with EC50 of 1.77 uM (GluR1(i)), 0.22 uM (GluR2(i)), 0.56 uM (GluR2(o)), 1.89 uM (GluR3(i)) and 0.20 uM (GluR4(i).
LY 392098 enhances a dose-dependent manner responses to AMPA, potentiates the synaptic excitation of dentate granule cells following perforant path stimulation in vivo.
| M.Wt | 335.44 | |
| Formula | C18H22FNO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-{2-[4-(2-fluorophenyl)phenyl]propyl}propane-2-sulfonamide |
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1. Miu P, et al. Neuropharmacology. 2001 Jun;40(8):976-83.
2. Gates M, et al. Neuropharmacology. 2001 Jun;40(8):984-91.
3. Vandergriff J, et al. Neuropharmacology. 2001 Jun;40(8):1003-9.
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