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LY450108

Chemical Structure : LY450108

CAS No.: 376594-67-1

LY450108 (LY 450108, LY-450108)

Catalog No.: PC-42745Not For Human Use, Lab Use Only.

LY450108 is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LY450108 is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.

Physicochemical Properties

M.Wt 396.4514
Formula C19H22F2N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-

References

1. O'Neill MJ, et al. Curr Drug Targets. 2007 May;8(5):603-20.

2. Jhee SS, et al. J Clin Pharmacol. 2006 Apr;46(4):424-32.

3. O'Neill MJ, et al. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94.

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