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LY451395

Chemical Structure : LY451395

CAS No.: 375345-95-2

LY451395 (Mibampator, LY 451395, LY-451395)

Catalog No.: PC-42744Not For Human Use, Lab Use Only.

Mibampator (LY451395) is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Mibampator (LY451395) is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.

Physicochemical Properties

M.Wt 438.6039
Formula C21H30N2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]-

References

1. O'Neill MJ, et al. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94.

2. Zmijewski M, et al. Drug Metab Dispos. 2006 Jun;34(6):925-31.

3. Malá H, et al. Behav Brain Res. 2012 Jan 1;226(1):18-25.

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