Catalog No.: PC-35276Not For Human Use, Lab Use Only.
LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein, inhibits Notch signalling in tumour cell lines and endothelial cells with IC50 of 0.005-20 nM.
LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein, inhibits Notch signalling in tumour cell lines and endothelial cells with IC50 of 0.005-20 nM.
LY900009 dose dependently inhibits Notch cleavage and induces apoptosis 24 h after a single 3 mg/kg oral dose in xenograft tumour models.
LY900009 also demonstrates inhibition of angiogenesis through formation of leaky vasculature.
