Lacutoclax | Bcl-2 inhibitor | Probechem Biochemicals

Chemical Structure : Lacutoclax

Lacutoclax (LP-108, LP108)

Catalog No.: PC-23094Not For Human Use, Lab Use Only.

Lacutoclax (LP-108) is a highly potent and selective inhibitor of BCL-2 with comparable or more potent in vitro inhibitory activity compared to venetoclax.

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Biological Activity

Lacutoclax (LP-108) is a highly potent and selective inhibitor of BCL-2 with comparable or more potent in vitro inhibitory activity compared to venetoclax.

Physicochemical Properties

M.Wt	923.53
Formula	C48H55ClN8O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-2-[(3R)-2,3-dihydro-3-methylpyrrolo[3′,2′:5,6]pyrido[2,3-b][1,4]oxazin-1(6H)-yl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]benzamide

References

1. Patent WO2021066873 A1 2021-04-08.

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Lacutoclax (LP-108, LP108)

Biological Activity

Physicochemical Properties

References

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