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Chemical Structure : Lanabecestat
CAS No.: 1383982-64-6
Catalog No.: PC-60045Not For Human Use, Lab Use Only.
Lanabecestat (AZD-3293, LY-3314814) is a potent, orally active and brain-permeable BACE1 inhibitor with Ki of 0.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Lanabecestat (AZD-3293, LY-3314814) is a potent, orally active and brain-permeable BACE1 inhibitor with Ki of 0.4 nM.
Lanabecestat (AZD-3293, LY-3314814) shows equipotency against hBACE2 (Ki=0.8 nM), >25,000- and >41,000-fold selectivity against cathepsin D and γ-secretase。
Lanabecestat (AZD-3293, LY-3314814) significantly reduces Aβ40, Aβ42, and sAβPPβ in mouse, guinea pig and dog, also shows in vitro potency in mouse and guinea pig primary cortical neuronal cells (IC50<1 nM)。
Lanabecestat (AZD-3293, LY-3314814) reduces cerebrospinal fluid (CSF) Aβ1-40 and Aβ1-42 in clinical trails.
| M.Wt | 412.537 | |
| Formula | C26H28N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine |
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1. Eketjäll S, et al. J Alzheimers Dis. 2016;50(4):1109-23.
2. Sims JR, et al. J Prev Alzheimers Dis. 2017;4(4):247-254.
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