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Lanatoside C

Chemical Structure : Lanatoside C

CAS No.: 17575-22-3

Lanatoside C

Catalog No.: PC-24059Not For Human Use, Lab Use Only.

Lanatoside C is a cardiac glycoside, has an IC50 of 0.19 μM for dengue virus (DENV) infection in HuH-7 cells, also potently inhibits FOXP3 activity by causing degradation of RUNX1, directly binds the E3 ligase STUB1 (ITC, Ka=13 uM).

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Biological Activity

Lanatoside C is a cardiac glycoside, has an IC50 of 0.19 μM for dengue virus (DENV) infection in HuH-7 cells, also potently inhibits FOXP3 activity by causing degradation of RUNX1,  directly binds the E3 ligase STUB1 (ITC, Ka=13 uM).
Lanatoside C effectively inhibits all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71.
Lanatoside C increases polyubiquitination and proteasomal degradation of RUNX1, disrupts the FOXP3/RUNX1 complex.
Lanatoside C inhibits Tregs activity and promotes antitumor immunity in a mouse primary lung cancer model.
Lanatoside C synergizes with PD-1 inhibitor to shrink lung cancers driven by mutant KRAS in a mouse model.

Physicochemical Properties

M.Wt 985.13
Formula C49H76O20
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3R,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-2-methyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl acetate

References

1. Cheung YY, et al. Antiviral Res. 2014 Nov;111:93-99.

2. Zhou Q, et al. EMBO Mol Med. 2025 Feb 20. doi: 10.1038/s44321-025-00200-y.

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