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Laniquidar

Chemical Structure : Laniquidar

CAS No.: 197509-46-9

Laniquidar (R-101933, R101933)

Catalog No.: PC-70022Not For Human Use, Lab Use Only.

Laniquidar (R101933) is an orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycoprotein.

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    Biological Activity

    Laniquidar (R101933) is an orally active, third-generation P-glycoprotein (P-gp) inhibitor that inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycoprotein.

    Physicochemical Properties

    M.Wt 584.7
    Formula C37H36N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl 11-(1-(4-(quinolin-2-ylmethoxy)phenethyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carboxylate

    References

    1. van Zuylen L, et al. Clin Cancer Res. 2000 Apr;6(4):1365-71.

    2. van Zuylen L, et al. Eur J Cancer. 2002 May;38(8):1090-9.

    3. Luurtsema G, et al. Nucl Med Biol. 2009 Aug;36(6):643-9.

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