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Lazertinib

Chemical Structure : Lazertinib

CAS No.: 1903008-80-9

Lazertinib (YH 25448, YH25448, GNS-1480, GNS1480)

Catalog No.: PC-60519Not For Human Use, Lab Use Only.

Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.
Lazertinib shows the beneficial for the NSCLC with brain metastasis.

Physicochemical Properties

M.Wt 554.66
Formula C30H34N8O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide

References

1. Patent US20160102076 A1.

2. Yun J, et al. Clin Cancer Res. 2019 Jan 22. pii: clincanres.2906.2018. doi: 10.1158/1078-0432.CCR-18-2906.

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