Lck Inhibitor 25 |CAS:847950-09-8 Probechem Biochemicals

Chemical Structure : Lck Inhibitor 25

Lck Inhibitor 25

Catalog No.: PC-42886Not For Human Use, Lab Use Only.

Lck Inhibitor 25 is a potent, selective Lck kinase inhibitor with IC50 of 7 nM, weakly inhibits Src and Lyn with IC50 of 42 and 21 nM, does not inhibits KDE and p38.

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Biological Activity

Lck Inhibitor 25 is a potent, selective Lck kinase inhibitor with IC50 of 7 nM, weakly inhibits Src and Lyn with IC50 of 42 and 21 nM, does not inhibits KDE and p38.
Lck Inhibitor 25 inhibits T cell proliferation in vitro and inhibits arthritis in in vivo models.

Physicochemical Properties

M.Wt	530.6229
Formula	C31H30N8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one, 6-(2,6-dimethylphenyl)-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-

References

1. Martin MW, et al. J Med Chem. 2008 Mar 27;51(6):1637-48.

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Lck Inhibitor 25

Biological Activity

Physicochemical Properties

References

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