Chemical Structure : Leelamine hydrochloride
CAS No.:
16496-99-4
Leelamine hydrochloride
(Dehydroabietylamine)
Catalog No. : PC-35497Not For Human Use, Lab Use Only.
Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR), inhibits castration-resistant prostate cancer cells.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-3549701
Biological Activity
Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR), inhibits castration-resistant prostate cancer cells; causes apoptosis and suppresses 22Rv1 xenograft growth in vivo; Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.
Physicochemical Properties
M.Wt
321.933
Formula
C20H32ClN
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, monohydrochloride
References
1. Singh KB, et al. Mol Cancer Ther. 2018 Jul 20. pii: molcanther.0117.2018.
2. Gowda R, et al. Oncotarget. 2017 Apr 25;8(17):28260-28277.
3. Sehrawat A, et al. Mol Carcinog. 2017 Feb;56(2):337-348.
4. Kuzu OF, et al. Mol Cancer Ther. 2014 Jul;13(7):1690-703.
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