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Chemical Structure : Lefamulin
CAS No.: 1061337-51-6
Catalog No.: PC-22410Not For Human Use, Lab Use Only.
Lefamulin (BC-3781) is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Lefamulin (BC-3781) is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer.
Lefamulin (BC-3781) exhibits a log-normal MIC distribution against the population of S. pneumoniae, with modal MIC, MIC50, and MIC90 results of 0.12, 0.12, and 0.25 μg/ml, respectively.
Lefamulin (BC-3781) exhibits potent antibacterial activity against the most important respiratory and skin pathogens, including Streptococcus spp. and Staphylococcus spp., fastidious Gram-negative organisms, such as Haemophilus influenzae, and atypical respiratory pathogens, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.
| M.Wt | 507.73 | |
| Formula | C28H45NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate |
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1. Waites KB, et al. Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02008-16.
2. Rubino CM, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):282-8.
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