Lefamulin (BC-3781) acetate | Antibiotic

Chemical Structure : Lefamulin acetate

CAS No.: 1350636-82-6

Lefamulin acetate (BC-3781 acetate, BC3781 acetate)

Catalog No.: PC-22409Not For Human Use, Lab Use Only.

Lefamulin (BC-3781) acetate is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer.

Packing	Price	Stock
5 mg	$178	In stock
10 mg	$298	In stock
25 mg	$478	In stock
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Biological Activity

Lefamulin (BC-3781) acetate is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer.
Lefamulin (BC-3781) exhibits a log-normal MIC distribution against the population of S. pneumoniae, with modal MIC, MIC50, and MIC90 results of 0.12, 0.12, and 0.25 μg/ml, respectively.
Lefamulin (BC-3781) exhibits potent antibacterial activity against the most important respiratory and skin pathogens, including Streptococcus spp. and Staphylococcus spp., fastidious Gram-negative organisms, such as Haemophilus influenzae, and atypical respiratory pathogens, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.

Physicochemical Properties

M.Wt	567.78
Formula	C30H49NO7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate acetate

References

1. Waites KB, et al. Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02008-16.

2. Rubino CM, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):282-8.

Lefamulin acetate (BC-3781 acetate, BC3781 acetate)

Biological Activity

Physicochemical Properties

References

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