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Chemical Structure : Leonurine
CAS No.: 24697-74-3
Catalog No.: PC-62213Not For Human Use, Lab Use Only.
Leonurine (SCM-198) is a natural alkaloid that exhibits cardio-and neuronal-protective effects both in vitro and in vivo, occupies the caspase recruitment site of Apaf-1, blocks its interaction with procaspase-9.
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|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | Get quote |
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Leonurine (SCM-198) is a natural alkaloid that exhibits cardio-and neuronal-protective effects both in vitro and in vivo, occupies the caspase recruitment site of Apaf-1, blocks its interaction with procaspase-9.
Leonurine (SCM-198) attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells, protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function, attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4 (Nox4).
| M.Wt | 311.338 | |
| Formula | C14H21N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 4-hydroxy-3,5-dimethoxy-, ester with (4-hydroxybutyl)guanidine (8CI) |
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1. Loh KP, et al. Stroke. 2010 Nov;41(11):2661-8.
2. Xin H, et al. Eur J Pharmacol. 2009 Jun 10;612(1-3):75-9.
3. Liu XH, et al. Free Radic Biol Med. 2013 Jan;54:93-104.
4. Wang Y, et al. Sci Rep. 2016 Jul 22;6:29820.
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