Catalog No.: PC-62213Not For Human Use, Lab Use Only.
Leonurine (SCM-198) is a natural alkaloid that exhibits cardio-and neuronal-protective effects both in vitro and in vivo, occupies the caspase recruitment site of Apaf-1, blocks its interaction with procaspase-9.
Leonurine (SCM-198) is a natural alkaloid that exhibits cardio-and neuronal-protective effects both in vitro and in vivo, occupies the caspase recruitment site of Apaf-1, blocks its interaction with procaspase-9.
Leonurine (SCM-198) attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells, protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function, attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4 (Nox4).
Physicochemical Properties
M.Wt
311.338
Formula
C14H21N3O5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Benzoic acid, 4-hydroxy-3,5-dimethoxy-, ester with (4-hydroxybutyl)guanidine (8CI)
References
1. Loh KP, et al. Stroke. 2010 Nov;41(11):2661-8.
2. Xin H, et al. Eur J Pharmacol. 2009 Jun 10;612(1-3):75-9.
3. Liu XH, et al. Free Radic Biol Med. 2013 Jan;54:93-104.
