Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Lerzeparib
Catalog No.: PC-23088Not For Human Use, Lab Use Only.
Lerzeparib (TQB3823) is a novel, potent and selective PARP inhibitor with IC50 of 2.8/0.9/629.3 nM for PARP1/PARP2/Tankyrase 1, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Lerzeparib (TQB3823) is a novel, potent and selective PARP inhibitor with IC50 of 2.8/0.9/629.3 nM for PARP1/PARP2/Tankyrase 1, respectively.
Lerzeparib (TQB3823) inhibits proliferation of BRCA1 mutant MDA-MB-436 cell with IC50 of 9.6 nM, shows little anti-proliferative activity in BRCA-wild type MDA-MB-231 cell with IC50 >10 μM.
Lerzeparib (TQB3823) demonstrated antitumor efficacy in dose dependent fashions with tumor regression was observed at 25 mg/kg in MDA-MB-436 CDX model.
| M.Wt | 365.41 | |
| Formula | C21H20FN3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Hu Yanbin, et al. Cancer Res (2021) 81 (13_Supplement): 2054.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
