Chemical Structure : Lestaurtinib
CAS No.:
111358-88-4
Lestaurtinib
(KT-5555;CEP-701)
Catalog No. : PC-70173Not For Human Use, Lab Use Only.
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7017301
Biological Activity
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2 , FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively.
Physicochemical Properties
M.Wt
439.46
Formula
C26H21N3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(5R,7S,8S)-7-hydroxy-7-(hydroxymethyl)-5,6,7,8,13,14-hexahydro-15H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-15-one
References
1. Hexner EO, et al. Blood.
2. Weisel KC, et al. Ann N Y Acad Sci.
3. Miknyoczki SJ, et al. Ann N Y Acad Sci.
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