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Chemical Structure : Lestaurtinib
CAS No.: 111358-88-4
Catalog No.: PC-70173Not For Human Use, Lab Use Only.
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $388 | In stock | |
| 5 mg | $588 | In stock | |
| 10 mg | $898 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively.
Lestaurtinib (KT-5555, CEP-701) also inhibits Aurora A and B (IC50=8.1 and 2.3 nM); prevents STAT5 phosphorylation (IC50= 20-30 nM).
Lestaurtinib (KT-5555, CEP-701) exhibits antiproliferative activity in vitro (IC50=30-100 nM in HEL92.1.7 cells).
| M.Wt | 439.46 | |
| Formula | C26H21N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5R,7S,8S)-7-hydroxy-7-(hydroxymethyl)-5,6,7,8,13,14-hexahydro-15H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-15-one |
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1. Hexner EO, et al. Blood. 2008 Jun 15;111(12):5663-71.
2. Weisel KC, et al. Ann N Y Acad Sci. 2007 Jun;1106:190-6.
3. Miknyoczki SJ, et al. Ann N Y Acad Sci. 1999 Jun 30;880:252-62.
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