Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Letaxaban
Catalog No.: PC-63359Not For Human Use, Lab Use Only.
Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA; In human plasma, TAK-442 doubles FXa-induced clotting time, prothrombin time (PT), and activated partial thromboplastin time at 0.19, 0.55, and 0.59 uM, respectively; demonstrates antithrombotic effects in rabbit model of venous thrombosis.
Thrombosis
Phase 2 Discontinued
| M.Wt | 479.98 | |
| Formula | C22H26ClN3O5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kawamura M, et al. J Cardiovasc Pharmacol. 2010 Aug;56(2):156-61.
2. Konishi N, et al. Thromb Res. 2010 Aug;126(2):124-9.
3. Konishi N, et al. Thromb Haemost. 2010 Sep;104(3):504-13.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
