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Leucettine L41

Chemical Structure : Leucettine L41

CAS No.: 1112978-84-3

Leucettine L41 (CLK inhibitor L41)

Catalog No.: PC-61025Not For Human Use, Lab Use Only.

Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.

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    Biological Activity

    Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
    Leucettine L41 inhibits the phosphorylation of serine/arginine-rich proteins (SRp), a family of proteins regulating pre-RNA splicing, modulates alternative pre-mRNA splicing in cell-based reporting system.
    Leucettine L41 induces mTOR-dependent autophagy, prevents Aβ25-35-induced memory impairments and neurotoxicity in the mouse hippocampus.

    Physicochemical Properties

    M.Wt 307.309
    Formula C17H13N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (5Z)-5-(1,3-Benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-4H-imidazol-4-one

    References

    1. Fant X, et al. Mol Pharmacol. 2014 Mar;85(3):441-50.

    2. Naert G, et al. Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82.

    3. Debdab M, et al. J Med Chem. 2011 Jun 23;54(12):4172-86.

    4. Tahtouh T, et al. J Med Chem. 2012 Nov 8;55(21):9312-30.

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