Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
Leucettine L41 inhibits the phosphorylation of serine/arginine-rich proteins (SRp), a family of proteins regulating pre-RNA splicing, modulates alternative pre-mRNA splicing in cell-based reporting system.
Leucettine L41 induces mTOR-dependent autophagy, prevents Aβ25-35-induced memory impairments and neurotoxicity in the mouse hippocampus.
