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Chemical Structure : Leucettine L41
Catalog No.: PC-61025Not For Human Use, Lab Use Only.
Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
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Leucettine L41 is a novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
Leucettine L41 inhibits the phosphorylation of serine/arginine-rich proteins (SRp), a family of proteins regulating pre-RNA splicing, modulates alternative pre-mRNA splicing in cell-based reporting system.
Leucettine L41 induces mTOR-dependent autophagy, prevents Aβ25-35-induced memory impairments and neurotoxicity in the mouse hippocampus.
| M.Wt | 307.309 | |
| Formula | C17H13N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fant X, et al. Mol Pharmacol. 2014 Mar;85(3):441-50.
2. Naert G, et al. Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82.
3. Debdab M, et al. J Med Chem. 2011 Jun 23;54(12):4172-86.
4. Tahtouh T, et al. J Med Chem. 2012 Nov 8;55(21):9312-30.
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