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Leupeptin hemisulfate

Chemical Structure : Leupeptin hemisulfate

CAS No.: 103476-89-7

Leupeptin hemisulfate

Catalog No.: PC-45438Not For Human Use, Lab Use Only.

Leupeptin hemisulfate is a potent, reversible inhibitor of cysteine, serine, and threonine proteases, inhibits cathepsin B (Ki=6 nM), calpain (Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 uM), and kallikrein (Ki=19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.

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Biological Activity

Leupeptin hemisulfate is a potent, reversible inhibitor of cysteine, serine, and threonine proteases, inhibits cathepsin B (Ki=6 nM), calpain (Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 uM), and kallikrein (Ki=19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.

Physicochemical Properties

M.Wt 475.59
Formula C20H38N6O4 . 1/2H2SO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 19 mg/mL

Chemical Name/SMILES

L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-, sulfate (2:1)

References

1. Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.

2. Mehdi S. Trends Biochem Sci. 1991 Apr;16(4):150-3.

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