Chemical Structure : Lexacalcitol
CAS No.:
131875-08-6
Lexacalcitol
(KH-1060)
Catalog No. : PC-45802Not For Human Use, Lab Use Only.
Aa potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4580201
Biological Activity
Aa potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy; stimulates the synthesis of sulphated glycosaminoglycans and hydroxyproline in skin treated with betamethasone; strongly stimulated the expression of TGF-beta 1 in betamethasone-impaired granulation tissue; a potent vitamin D receptor agonist.
Physicochemical Properties
M.Wt
460.689
Formula
C29H48O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-
References
1. Gniadecki R, et al. Br J Pharmacol. 1994 Oct;113(2):439-44.
2. Gniadecki R, et al. J Endocrinol. 1994 Jun;141(3):411-5.
3. Sandler S, et al. Immunol Lett. 1994 Jun;41(1):73-7.
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