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Lificiguat

Chemical Structure : Lificiguat

CAS No.: 170632-47-0

Lificiguat (YC-1;YC 1)

Catalog No.: PC-44126Not For Human Use, Lab Use Only.

Lificiguat (YC-1) is an NO-independent, superoxide-sensitive stimulator of sGC (soluble guanylyl cyclase) with EC50 of 18.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lificiguat (YC-1) is an NO-independent, superoxide-sensitive stimulator of sGC (soluble guanylyl cyclase) with EC50 of 18.6 uM.
YC-1 elicits only minor effects on relaxation and cyclic GMP, increases the vasodilator potency of SNP and nitroglycerin (NTG) by 10 fold.
YC-1 markedly enhances SNP- and NTG-induced cyclic GMP formation at 3 uM.

Physicochemical Properties

M.Wt 304.3425
Formula C19H16N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 51 mg/mL

Chemical Name/SMILES

2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]-

References

1. Mülsch A, et al. Br J Pharmacol. 1997 Feb;120(4):681-9.

2. Purohit R, et al. Biochemistry. 2014 Jan 14;53(1):101-14.

3. Friebe A, et al. Mol Pharmacol. 1998 Jan;53(1):123-7.

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