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Chemical Structure : Linaclotide
CAS No.: 851199-59-2
Catalog No.: PC-45371Not For Human Use, Lab Use Only.
Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist (Ki=1.23-1.64 nM) that elicits pharmacological effects locally in the gastrointestinal tract.
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 50 mg | $398 | In stock | |
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Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist (Ki=1.23-1.64 nM) that elicits pharmacological effects locally in the gastrointestinal tract.
Linaclotide induces a significant increase in fluid secretion, accompanied by a significant increase in intraluminal cGMP levels.
Linaclotide has potential for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
| M.Wt | 1526.736 | |
| Formula | C59H79N15O21S6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide) |
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1. Bryant AP, et al. Life Sci. 2010 May 8;86(19-20):760-5.
2. Eutamene H, et al. Neurogastroenterol Motil. 2010 Mar;22(3):312-e84.
3. Busby RW, et al. Eur J Pharmacol. 2010 Dec 15;649(1-3):328-35.
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