Chemical Structure : Linopirdine dihydrochloride
CAS No.:
113168-57-3
Linopirdine dihydrochloride
(DUP-996 dihydrochloride)
Catalog No.: PC-63068Not For Human Use, Lab Use Only.
Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.
Linopirdine blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
Linopirdine inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.
Physicochemical Properties
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M.Wt
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464.39
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Formula
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C26H21N3O.2HCl
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
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References
1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.
2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.
3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
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