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Linrodostat

Chemical Structure : Linrodostat

CAS No.: 1923833-60-6

Linrodostat (BMS-986205, F-001287, ONO-7701)

Catalog No.: PC-60068Not For Human Use, Lab Use Only.

Linrodostat (BMS-986205, F-001287, ONO-7701) is a novel potent, selective and orally available IDO1 inhibitor with IC50 of 1.1 nM in cell-based assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Linrodostat (BMS-986205, F-001287, ONO-7701) is a novel potent, selective and orally available IDO1 inhibitor with IC50 of 1.1 nM in cell-based assays.
BMS-986205 has no inhibitory activity on TDO, potently inhibits kynurenine (kyn) production in IDO1-HEK293 cells with IC50 of 1.1 nM;.
BMS-986205 shows potential with superior PD properties and support further evaluation in combination with vivo.

Physicochemical Properties

M.Wt 410.912
Formula C24H24ClFN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R)-N-(4-Chlorophenyl)-2-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]propanamide

References

1. Richards T, et al. Oncotarget. 2018 Jul 20;9(56):30814-30820.    2. Lillian L. Siu, et al. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116.

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