You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-IGF-1R-Linsitinib
Linsitinib

Chemical Structure : Linsitinib

CAS No.: 867160-71-2

Linsitinib (ASP-7487;ASP 7487;OSI-906;OSI906)

Catalog No.: PC-42436Not For Human Use, Lab Use Only.

Linsitinib (ASP-7487, OSI-906) is a potent, selective, orally active, dual IGF-1R/insulin receptor inhibitor with IC50 of 35/75 nM, respectively.

Packing Price Stock Quantity
2 mg (Free Sample) $28 In stock
10 mg $138 In stock
25 mg $228 In stock
50 mg $378 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Linsitinib (ASP-7487, OSI-906) is a potent, selective, orally active, dual IGF-1R/insulin receptor inhibitor with IC50 of 35/75 nM, respectively.
Linsitinib (ASP-7487, OSI-906) potently and selectively inhibits autophosphorylation of both human IGF-1R and IR, displays in vitro antiproliferative effects in a variety of tumor cell lines.
Linsitinib (ASP-7487, OSI-906) shows robust in vivo anti-tumor efficacy in an IGF-1R-driven xenograft model.

Physicochemical Properties

M.Wt 421.4937
Formula C26H23N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-, cis-

References

1. Mulvihill MJ, et al. Future Med Chem. 2009 Sep;1(6):1153-71.

2. Pitts TM, et al. Clin Cancer Res. 2010 Jun 15;16(12):3193-204.

3. Buck E, et al. Mol Cancer Ther. 2010 Oct;9(10):2652-64.

4. Kuhn DJ, et al. Blood. 2012 Oct 18;120(16):3260-70.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: