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Liquidambaric acid

Chemical Structure : Liquidambaric acid

CAS No.: 4481-62-3

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Liquidambaric acid ((+)-Betulonic acid, Betulonic acid)

Catalog No.: PC-20658Not For Human Use, Lab Use Only.

Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays.
TRAF2 is a positive regulator of Wnt/β-catenin signaling and colon cancer.
Liquidambaric acid disrupts the interaction between TRAF2 and β-catenin in both MST and coIP assays.
Liquidambaric acid inhibits TRAF2/β-catenin/TCF4/TNIK complex formation in colon cancer.

Physicochemical Properties

M.Wt 454.70
Formula C30H46O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,3aR,5aS,5bS,7aS,11aS,11bS,13aS,13bS)-5a,5b,8,8,11a-pentamethyl-9-oxo-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid

References

1. Yan R, et al. Cell Rep. 2022 Feb 1;38(5):110319.

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