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Chemical Structure : Lisaftoclax
CAS No.: 2180923-05-9
Catalog No.: PC-72311Not For Human Use, Lab Use Only.
Lisaftoclax (APG-2575) is a novel BCL-2 selective inhibitor with binding Ki of < 0.1/0.1 nM for Bcl-2/Bcl-XL, no binding affinity against BCL-W/MCL-1.
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Lisaftoclax (APG-2575) is a novel BCL-2 selective inhibitor with binding Ki of < 0.1/0.1 nM for Bcl-2/Bcl-XL, no binding affinity against BCL-W/MCL-1.
APG-2575 effectively suppressed DLBCL with BCL-2 high expression via activating the mitochondrial apoptosis pathway.
APG-2575 showed strong synergic effect with mouse double minute 2 (MDM2)–p53 inhibitor APG-115 that can achieve potent antitumor effect and markedly prolong survival in animal models.
| M.Wt | 882.4 | |
| Formula | C45H48ClN7O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (88.2 mg/mL) |
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| Chemical Name/SMILES |
4-[4-[[8-(4-chlorophenyl)spiro[3.5]non-7-en-7-yl]methyl]piperazin-1-yl]-N-[4-[[(2S)-1,4-dioxan-2-yl]methylamino]-3-nitrophenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide |
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1. Luo Q, et al. Oncol Res. 2020 Sep 1;28(4):331-344.
2. Fang DD, et al. Transl Oncol. 2022 Jan;15(1):101244.
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