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Lixisenatide

Chemical Structure : Lixisenatide

CAS No.: 320367-13-3

Lixisenatide (ZP10A)

Catalog No.: PC-47501Not For Human Use, Lab Use Only.

Lixisenatide (ZP10A) is a peptide glucagon-like peptide 1 (GLP-1) receptor agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lixisenatide (ZP10A) is a peptide glucagon-like peptide 1 (GLP-1) receptor agonist.
Lixisenatide (ZP10A) exhibits 4-fold higher affinity for the human GLP-1 receptor than GLP-1 (7-36) amide.
Lixisenatide (ZP10A) demonstrated dose-dependent improvement of glucose tolerance with an ED50 value of 0.02 nmol/kg i.p. in an oral glucose tolerance test (OGTT) in diabetic db/db mice. 

Physicochemical Properties

M.Wt 4858.49
Formula C215H347N61O65S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 20 mM

Chemical Name/SMILES

His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH2

References

1. Umpierrez GE, et al. Diabetes Obes Metab. 2017 Mar 3.
2. Mezquita-Raya P, et al. Diabetes Ther. 2017 Apr;8(2):401-415.
3. Thorkildsen C, et al. J Pharmacol Exp Ther. 2003 Nov;307(2):490-6.

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