Catalog No.: PC-24772Not For Human Use, Lab Use Only.
Lomitapide (AEGR-733, BMS-201038) is a highly potent inhibitor of microsomal triglyceride-transfer protein (MTP), inhibits triglyceride transfer of human MTP in vitro with IC50 of 0.5 nM, inhibits secretion of apoB from HepG2 cells with IC50 of 0.8 nM.
Lomitapide (AEGR-733, BMS-201038) is a highly potent inhibitor of microsomal triglyceride-transfer protein (MTP), inhibits triglyceride transfer of human MTP in vitro with IC50 of 0.5 nM, inhibits secretion of apoB from HepG2 cells with IC50 of 0.8 nM. Lomitapide inhibited the production of lipoprotein particles in rodent models and normalized plasma lipoprotein levels in Watanabe-heritable hyperlipidemic (WHHL) rabbits, which are a model for human homozygous familial hypercholesterolemia.
