Lomonitinib | FLT3/IRAK4 inhibitor | Probechem Biochemicals

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Chemical Structure : Lomonitinib

Lomonitinib (ZE46-0134)

Catalog No.: PC-24149Not For Human Use, Lab Use Only.

Lomonitinib (ZE46-0134) is a highly potent and selective pan-FLT3/IRAK4 inhibitor, targets clinically relevant FLT3 mutations (ITD, TKD) including the gatekeeper mutation, as well as IRAK4, a putative escape pathway for FLT3-driven acute myeloid leukemia (AML).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	436.52
Formula	C27H24N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3,4-dimethoxyphenyl)-1-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1H-pyrazolo[4,3-c]quinoline

References

1. Patent WO2023064133 A1.

2. Tara L. Lin, et al. Blood (2024) 144 (Supplement 1): 2883.4.

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Lomonitinib (ZE46-0134)

Biological Activity

Physicochemical Properties

References

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