Chemical Structure : Longdaysin
CAS No.: 1353867-91-0
Catalog No.: PC-28448Not For Human Use, Lab Use Only.
Longdaysin is a potent modulator of circadian rhythms targeting protein kinases CKIδ, CKIα, and ERK2, inhibits CKIα-mediated phosphorylation stimulated degradation of a clock protein PER1, drastically lengthens circadian period in vivo, also inhibits Wnt/β-catenin signaling and exhibits antitumor activity against breast cancer.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | Get quote |
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Longdaysin is a potent modulator of circadian rhythms targeting protein kinases CKIδ, CKIα, and ERK2, inhibits CKIα-mediated phosphorylation stimulated degradation of a clock protein PER1, drastically lengthens circadian period in vivo, also inhibits Wnt/β-catenin signaling and exhibits antitumor activity against breast cancer.
| M.Wt | 335.33 | |
| Formula | C16H16F3N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine |
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1. Hirota T, et al. PLoS Biol. 2010 Dec 14;8(12):e1000559.
2. Weger M, et al. Dev Biol. 2013 Aug 15;380(2):259-73.
3. Lee JW, et al. J Med Chem. 2019 Feb 28;62(4):1989-1998.
4. Xiong Y, et al. Onco Targets Ther. 2019 Feb 5;12:993-1005.

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