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Longdaysin

Chemical Structure : Longdaysin

CAS No.: 1353867-91-0

Longdaysin

Catalog No.: PC-28448Not For Human Use, Lab Use Only.

Longdaysin is a potent modulator of circadian rhythms targeting protein kinases CKIδ, CKIα, and ERK2, inhibits CKIα-mediated phosphorylation stimulated degradation of a clock protein PER1, drastically lengthens circadian period in vivo, also inhibits Wnt/β-catenin signaling and exhibits antitumor activity against breast cancer.

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Biological Activity

Longdaysin is a potent modulator of circadian rhythms targeting protein kinases CKIδ, CKIα, and ERK2, inhibits CKIα-mediated phosphorylation stimulated degradation of a clock protein PER1, drastically lengthens circadian period in vivo, also inhibits Wnt/β-catenin signaling and exhibits antitumor activity against breast cancer.

Physicochemical Properties

M.Wt 335.33
Formula C16H16F3N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine

References

1. Hirota T, et al. PLoS Biol. 2010 Dec 14;8(12):e1000559.

2. Weger M, et al. Dev Biol. 2013 Aug 15;380(2):259-73.

3. Lee JW, et al. J Med Chem. 2019 Feb 28;62(4):1989-1998.

4. Xiong Y, et al. Onco Targets Ther. 2019 Feb 5;12:993-1005.

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