Lonitoclax

Chemical Structure : Lonitoclax

Catalog No.: PC-24151Not For Human Use, Lab Use Only.

Lonitoclax is a potent, selective next generation BCL-2 inhibitor, a key pro-survival protein that is overexpressed in many cancers, for the treatment of AML and CLL.

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Biological Activity

Lonitoclax is a potent, selective next generation BCL-2 inhibitor, a key pro-survival protein that is overexpressed in many cancers, for the treatment of AML and CLL.

Physicochemical Properties

M.Wt	733.31
Formula	C43H45ClN4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(5-chloro-2-(3-(morpholinomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-N-(4-hydroxyphenyl)-N-(3-methoxy-2-methylbenzyl)-1,2-dimethyl-1H-pyrrole-3-carboxamide

References

1. Patent WO2023129553 A1.

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Lonitoclax

Biological Activity

Physicochemical Properties

References

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