Chemical Structure : Lorlatinib
CAS No.:
1454846-35-5
Lorlatinib
(PF-06463922, PF 06463922, PF06463922)
Catalog No. : PC-42919Not For Human Use, Lab Use Only.
Lorlatinib (PF-06463922) is a potent, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with IC50 of 0.07/0.025 nM respectively.
Packing Price Stock Quantity 5 mg (Free Sample) $28 In stock 0 1 2 3 4 5 25 mg $148 In stock 0 1 2 3 4 5 50 mg $228 In stock 0 1 2 3 4 5 100 mg $358 In stock 0 1 2 3 4 5 250 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4291901
Biological Activity
Lorlatinib (PF-06463922) is a potent, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with IC50 of 0.07/0.025 nM respectively.ALK L1196M (IC50=0.7 nM) and exhibits selectivity >100-fold for ROS1 over 204 kinases.
Physicochemical Properties
M.Wt
406.413
Formula
C21H19FN6O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 28 mg/mL
Chemical Name/SMILES
2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-
References
1. Zou HY, et al. Proc Natl Acad Sci U S A.
2. Johnson TW, et al. J Med Chem
3. Infarinato NR, et al. Cancer Discov.
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