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Chemical Structure : Lorlatinib
CAS No.: 1454846-35-5
Catalog No.: PC-42919Not For Human Use, Lab Use Only.
Lorlatinib (PF-06463922) is a potent, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with IC50 of 0.07/0.025 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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Lorlatinib (PF-06463922) is a potent, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with IC50 of 0.07/0.025 nM respectively.
Lorlatinib (PF-06463922) also inhibits ALK L1196M (IC50=0.7 nM) and exhibits selectivity >100-fold for ROS1 over 204 kinases.
Lorlatinib (PF-06463922) inhibits crizotinib-resistant mutant ROS1G2032R and ROS1L2026M and orally available in vivo.
| M.Wt | 406.413 | |
| Formula | C21H19FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- |
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1. Zou HY, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3493-8.
2. Johnson TW, et al. J Med Chem. 2014 Jun 12;57(11):4720-44.
3. Infarinato NR, et al. Cancer Discov. 2016 Jan;6(1):96-107.
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