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Chemical Structure : Losmapimod
CAS No.: 585543-15-3
Catalog No.: PC-42564Not For Human Use, Lab Use Only.
Losmapimod (GSK-AHAB, GW856553X, SB856553) is a selective, potent, orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $348 | In stock | |
| 250 mg | Get quote |
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Losmapimod (GSK-AHAB, GW856553X, SB856553) is a selective, potent, orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
Losmapimod (GSK-AHAB, GW856553X, SB856553) displays no significant activity for p38γ, p38δ (<25% inhibition at 10 uM), and COX-2.
Losmapimod (GSK-AHAB, GW856553X, SB856553) significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation in rat model of cardiovascular disease.
| M.Wt | 383.4591 | |
| Formula | C22H26FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 58 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)- |
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1. Willette RN, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):964-70.
2. Cheriyan J, et al. Circulation. 2011 Feb 8;123(5):515-23.
3. Lomas DA, et al. J Clin Pharmacol. 2012 Mar;52(3):416-24.
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