Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Lu AF-58027
Lu AF-58027

Chemical Structure : Lu AF-58027

CAS No.: 1255919-63-1

Add to Favorites

Lu AF-58027 (Lu AF58027)

Catalog No.: PC-61343Not For Human Use, Lab Use Only.

Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively.
    Lu AF-58027 shows no signigicant inhibitory effects at other PDEs (at least micromolar concentrations).
    Lu AF-58027 induces concentration-dependent relaxations reduced by ODQ and SQ22536 in rat isolated mesenteric arteries.
    Lu AF-58027 dose-dependently lowers mean BP and increases heart rate in anaesthetized rats.

    Physicochemical Properties

    M.Wt 486.62
    Formula C28H34N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-isobutyl-5-methyl-2-(4-(1-methylpyrrolidin-2-yl)benzyl)-3-(phenylamino)-2,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione

    References

    1. Laursen M, et al. Br J Pharmacol. 2017 Aug;174(15):2563-2575.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: