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Chemical Structure : Lu AF-58027
Catalog No.: PC-61343Not For Human Use, Lab Use Only.
Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively.
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Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively.
Lu AF-58027 shows no signigicant inhibitory effects at other PDEs (at least micromolar concentrations).
Lu AF-58027 induces concentration-dependent relaxations reduced by ODQ and SQ22536 in rat isolated mesenteric arteries.
Lu AF-58027 dose-dependently lowers mean BP and increases heart rate in anaesthetized rats.
| M.Wt | 486.62 | |
| Formula | C28H34N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Laursen M, et al. Br J Pharmacol. 2017 Aug;174(15):2563-2575.
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