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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Monoamine Transporter-Lu AF60097
Lu AF60097

Chemical Structure : Lu AF60097

CAS No.: 2507890-46-0

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Lu AF60097 (Lu AF 60097)

Catalog No.: PC-20763Not For Human Use, Lab Use Only.

Lu AF60097 is a high affinity, allosteric inhibitor of serotonin transporter (SERT) inhibitor with IC50 of 31 nM for inhibition of [3H]IMI dissociation, targets the extracellular vestibule (S2 site).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Lu AF60097 is a high affinity, allosteric inhibitor of serotonin transporter (SERT) inhibitor with IC50 of 31 nM for inhibition of [3H]IMI dissociation, targets the extracellular vestibule (S2 site).
Lu AF60097 inhibited [3H]5-HT uptake with an IC50 of 207 nM in hSERT expressed in COS-7 cells.
Lu AF60097 and imipramine can block SERT synergistically.
Lu AF60097 (250 nM) increases hippocampal 5-HT levels in rat hippocampus.

Physicochemical Properties

M.Wt 525.62
Formula C32H32FN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=CC2=C([C@](CCCN3CCC(C4=CC5=C(C=C4)C=CC(N5)=O)CC3)(C6=CC=C(F)C=C6)OC2)C=C1)N

References

1. Per Plenge, et al. Nature Communications volume 11, Article number: 1491 (2020)

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