Lumateperone (ITI-007)

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Chemical Structure : Lumateperone

CAS No.: 313368-91-1

Catalog No.: PC-70076Not For Human Use, Lab Use Only.

Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).

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25 mg	$38	In stock
100 mg	$78	In stock
250 mg	$128	In stock
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Biological Activity

Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
Lumateperone also shows affinity for D1.
Lumateperone is orally bioavailable and exhibits good antipsychotic efficacy in vivo.

Physicochemical Properties

M.Wt	393.496
Formula	C24H28FN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one

References

1. Li P, et al. J Med Chem. 2014 Mar 27;57(6):2670-82.

2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.

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