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Chemical Structure : Lumateperone
Catalog No.: PC-70076Not For Human Use, Lab Use Only.
Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
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Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM); also shows affinity for D1; orally bioavailable and exhibits good antipsychotic efficacy in vivo.
Schizophrenia
Phase 3 Clinical
| M.Wt | 393.496 | |
| Formula | C24H28FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li P, et al. J Med Chem. 2014 Mar 27;57(6):2670-82.
2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.
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