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Lumateperone tosylate

Chemical Structure : Lumateperone tosylate

CAS No.: 1187020-80-9

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Lumateperone tosylate (ITI-007)

Catalog No.: PC-45693Not For Human Use, Lab Use Only.

Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM); also shows affinity for D1; orally bioavailable and exhibits good antipsychotic efficacy in vivo.

Schizophrenia

Phase 3 Clinical

Physicochemical Properties

M.Wt 565.6987
Formula C31H36FN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-, 4-methylbenzenesulfonate (1:1)

References

1. Li P, et al. J Med Chem. 2014 Mar 27;57(6):2670-82.

2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.

3. Davis RE, et al. Psychopharmacology (Berl). 2015 Aug;232(15):2863-72.

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