Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Lurbinectedin
CAS No.: 497871-47-3
Catalog No.: PC-38616Not For Human Use, Lab Use Only.
Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $278 | In stock | |
| 5 mg | $588 | In stock | |
| 10 mg | $898 | In stock | |
| 25 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
Lurbinectedin (PM01183) inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer.
Lurbinectedin (PM01183) attenuates nucleotide excision repair (NER) and shows activity toward platinum-resistant cells.
Lurbinectedin (PM01183) inactivates EWS-FLI1 transcription factor by redistributing the protein within the nucleus to the nucleolus.
| M.Wt | 784.881 | |
| Formula | C41H44N4O10S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′-[1H]pyrido[3,4-b]indol]-19-one, 5-(acetyloxy)-2′,3′,4′,6,6a,7,9′,13,14,16-decahydro-8,14-dihydroxy-6′,9-dimethoxy-4,10,23-trimethyl-, (1′R,6R,6aR,7R,13S,14S,16R)- |
|
1. Vidal A, et al. Clin Cancer Res. 2012 Oct 1;18(19):5399-411.
2. Soares DG, et al. Mol Cancer Ther. 2011 Aug;10(8):1481-9.
3. Elez ME, et al. Clin Cancer Res. 2014 Apr 15;20(8):2205-14.
4. Harlow ML, et al. Cancer Res. 2016 Nov 15;76(22):6657-6668.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
