Lurbinectedin (PM01183) | DNA covalent binder

Chemical Structure : Lurbinectedin

CAS No.: 497871-47-3

Lurbinectedin (PM01183, ZEPZELCA)

Catalog No.: PC-38616Not For Human Use, Lab Use Only.

Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.

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1 mg	$278	In stock
5 mg	$588	In stock
10 mg	$898	In stock
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Biological Activity

Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
Lurbinectedin (PM01183) inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer.
Lurbinectedin (PM01183) attenuates nucleotide excision repair (NER) and shows activity toward platinum-resistant cells.
Lurbinectedin (PM01183) inactivates EWS-FLI1 transcription factor by redistributing the protein within the nucleus to the nucleolus.

Physicochemical Properties

M.Wt	784.881
Formula	C41H44N4O10S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′-[1H]pyrido[3,4-b]indol]-19-one, 5-(acetyloxy)-2′,3′,4′,6,6a,7,9′,13,14,16-decahydro-8,14-dihydroxy-6′,9-dimethoxy-4,10,23-trimethyl-, (1′R,6R,6aR,7R,13S,14S,16R)-

References

1. Vidal A, et al. Clin Cancer Res. 2012 Oct 1;18(19):5399-411.

2. Soares DG, et al. Mol Cancer Ther. 2011 Aug;10(8):1481-9.

3. Elez ME, et al. Clin Cancer Res. 2014 Apr 15;20(8):2205-14.

4. Harlow ML, et al. Cancer Res. 2016 Nov 15;76(22):6657-6668.

Lurbinectedin (PM01183, ZEPZELCA)

Biological Activity

Physicochemical Properties

References

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