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Chemical Structure : Luseogliflozin
Catalog No.: PC-61383Not For Human Use, Lab Use Only.
A potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1.
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Luseogliflozin (TS-071) is a potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1.
Luseogliflozin (TS-071) exhibits a blood glucose lowering effect, excellent urinary glucose excretion properties, and promising PK profiles in vivo.
Luseogliflozin (TS-071) increases urinary glucose excretion in Zucker fatty rats and beagle dogs at doses of 0.3 and 0.03 mg/kg respectively.
Luseogliflozin (TS-071) improves glucose tolerance without stimulating insulin secretion and reduces hyperglycaemia in STZ-induced diabetic rats.
| M.Wt | 434.547 | |
| Formula | C23H30O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kakinuma H, et al. J Med Chem. 2010 Apr 22;53(8):3247-61.
2. Yamamoto K, et al. Br J Pharmacol. 2011 Sep;164(1):181-91.
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