Chemical Structure : Luseogliflozin
CAS No.:
898537-18-3
Luseogliflozin
(TS-071;TS071)
Catalog No.: PC-61383Not For Human Use, Lab Use Only.
A potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Luseogliflozin (TS-071) is a potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1.
Luseogliflozin (TS-071) exhibits a blood glucose lowering effect, excellent urinary glucose excretion properties, and promising PK profiles in vivo.
Luseogliflozin (TS-071) increases urinary glucose excretion in Zucker fatty rats and beagle dogs at doses of 0.3 and 0.03 mg/kg respectively.
Luseogliflozin (TS-071) improves glucose tolerance without stimulating insulin secretion and reduces hyperglycaemia in STZ-induced diabetic rats.
Physicochemical Properties
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M.Wt
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434.547
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Formula
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C23H30O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,3R,4R,5S,6R)-2-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-6-(hydroxymethyl)thiane-3,4,5-trio
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References
1. Kakinuma H, et al. J Med Chem. 2010 Apr 22;53(8):3247-61.
2. Yamamoto K, et al. Br J Pharmacol. 2011 Sep;164(1):181-91.
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