Catalog No.: PC-28205Not For Human Use, Lab Use Only.
Lvguidingan is a piperine derivative and antiepileptic candidate with broad-spectrum anticonvulsant activity, inhibits Nav1.2 with low-micromolar potency (IC50=6.16 uM) and exhibits differential inhibitory effects across voltage-gated sodium channel subtypes.
Lvguidingan is a piperine derivative and antiepileptic candidate with broad-spectrum anticonvulsant activity, inhibits Nav1.2 with low-micromolar potency (IC50=6.16 uM) and exhibits differential inhibitory effects across voltage-gated sodium channel subtypes. Lvguidingan inhibited Nav1.2 in a state-dependent and use-dependent manner and altered channel gating. Lvguidingan suppressed hippocampal neuronal excitability. inhibited epilepsy-associated SCN2A gain-of-function variants.
Physicochemical Properties
M.Wt
272.17
Formula
C13H15Cl2NO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(sec-Butyl)-3-(3,4-dichlorophenyl)acrylamide
References
1. Wang L, et al. Acta Pharmacol Sin. 2026 Sep 15. doi: 10.1038/s41401-026-01931-5.
