Catalog No.: PC-60433Not For Human Use, Lab Use Only.
M2698 (MSC2363318A) is a potent, selective, ATP-competitive, orally bioavailable and brain penetrant dual inhibitor of p70S6K and Akt1/3 with IC50 of 1 nM and 17 nM, respectively.
M2698 (MSC2363318A) is a potent, selective, ATP-competitive, orally bioavailable and brain penetrant dual inhibitor of p70S6K and Akt1/3 with IC50 of 1 nM and 17 nM, respectively.
M2698 displays relative selectivity against a panel of 264 kinases (only 6 kinases within 10-fold IC50 of p70S6K).
M2698 inhibits the phosphorylation of p70S6K1 and Akt substrates, S6 (IC50=11 nM) and GSK3β (IC50=17 nM) in MDA-MB-468 cells, shows proliferation inhibition of 9 breast cancer cell lines (IC50<2 uM).
M2698 inhibits growth of human breast cancer xenografted tumors in mice.
