M351-0056 (M351-056)

Chemical Structure : M351-0056

CAS No.: 1189495-81-5

Catalog No.: PC-38590Not For Human Use, Lab Use Only.

M351-0056 (M351-056) is a small molecule VISTA agonist with high affinity KD of 12.6 uM, inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, regulates type I interferon (IFN-I) and non-canonical NF-κB pathways.

Packing	Price	Stock
5 mg	$218	In stock
10 mg	$348	In stock
25 mg	$548	In stock
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Biological Activity

M351-0056 (M351-056) is a small molecule VISTA agonist with high affinity KD of 12.6 uM, inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, regulates type I interferon (IFN-I) and non-canonical NF-κB pathways.

M351-0056 decreases the levels of cytokines (IFN-γ, IL-17A, TNF-α, IL-2 and IL-1β).

M351-0056 improves imiquimod-induced psoriasis-like skin inflammation, reduces autoantibody levels, kidney damage and immune cell expansion in mice susceptible to chronic graft-versus-host disease and lupus, and delays the progression of systemic lupus erythematosus.

Physicochemical Properties

M.Wt	447.355
Formula	C15H12BrFN2O2S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromo-2-fluorophenyl)-2-methyl-5-(2-methylthiazol-4-yl)thiophene-3-sulfonamide

References

1. Patent CN108743590, Small molecule compound having affinity with VISTA and use thereof. 2. Hu X, et al. Br J Pharmacol. 2021 Mar;178(6):1445-1458.